Publications

2026

Molly G Zych, Maya Contreras, Anna E Mammel, Emily M Hatch. "RCC1 depletion drives protein transport defects and rupture in micronuclei." J Cell Biol. (2026)

2025

Lucian DiPeso, Sriram Pendyala, Heather Z Huang, Douglas M Fowler, Emily M Hatch. "Image-based identification and isolation of micronucleated cells to dissect cellular consequences". eLife. (2025)

2024

Sara Martin, Simone Scorzoni,  Sara Cordone, Alice Mazzagatti, Galina V Beznoussenko, Amanda L Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A Mironov, Alessandro Cuomo, Uri Ben-David, Samuel F Bakhoum, Emily M Hatch, Peter Ly, Stefano Santaguida. "A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements". Science. (2024)

Molly G Zych, Emily M Hatch. "Small spaces, big problems: The abnormal nucleoplasm of micronuclei and its consequences." Review. Curr Opin Struct Biol. (2024)

Amanda L Gunn, Artem I Yashchenko, Julien Dubrulle, Jodiene Johnson, Emily M Hatch. "A high-content screen reveals new regulators of nuclear membrane stability." Sci. Rep. (2024).

2021

Anna E Mammel, Heather Z Huang, Amanda L Gunn, Emma Choo, Emily M Hatch. "Chromosome length and gene density contribute to micronuclear membrane stability." Life Sci Alliance. (2021).

Anna E Mammel, Emily M Hatch. "Genome instability from nuclear catastrophe and DNA damage". Review. Semin Cell Dev Biol. Apr 7 (2021).

Athena Vichas, Naomi T Nkinsi, Amanda K Riley, Phoebe CR Parrish, Fujiko Duke, April Lo, Jennifer Chen, Iris Fung, Jaqueline Watson, Austin M Gabel, Matthew Rees, James D Thomas, John K Lee, Marina K Baine, Natasha Rekhtman, Mark Ladanyi, Federica Piccioni, Robert K Bradley, Emily M Hatch, Alice H Berger. "Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer." Nat Commun. (2021).

2020

Alexandra M Young, Amanda L Gunn, Emily M Hatch. "BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins." Mol Biol Cell. (2020).

Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler. "High-throughput, microscope-based sorting to dissect cellular heterogeneity". Mol. Systems Biol. (2020). 

John Maciejowski*, Emily M Hatch*. Nuclear membrane rupture and its consequences” Review. Annu. Rev. Cell Dev. Biol. (2020). 

2018

Emily M Hatch. "Nuclear envelope rupture: little holes, big openings." Review. Curr Opin Cell Biol. (2018).

2016

Emily M Hatch ."Y chromothripsis?" Preview. Nat Cell Biol. (2016).

Emily M Hatch and Martin W Hetzer. "Nuclear envelope rupture is induced by actin-based nucleus confinement.” J Cell Biol. (2016).

2015

Mertens J, Paquola AC, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell Stem Cell, (2015).

Emily M Hatch and Martin W Hetzer “Linking micronuclei to chromosome fragmentation.” Preview. Cell, (2015).

Emily M Hatch and Martin W Hetzer “Chromothripsis.” Review. Curr Biol., (2015).

2014

Emily M Hatch and Martin W Hetzer “Breaching the nuclear envelope in development and disease.” Review. J Cell Biol., (2014).

2013

Emily M Hatch, Andrew H Fisher, Thomas J Deerinck, Martin W Hetzer “Catastrophic nuclear envelope collapse in cancer cell micronuclei.” Cell, (2013).

2012

Emily M Hatch and Martin W Hetzer “RNP export by nuclear envelope budding.” Review. Cell, (2012).

Jesse D Vargas, Emily M Hatch, Daniel J Anderson, Martin W Hetzer “Transient nuclear envelope rupturing during interphase in human cancer cells.” Nucleus, (2012).